New UKGTN Genetic Test Recommendations for NHS Service approved by the Clinical & Scientific Advisory Group September 2015

25 September 2015

The UKGTN Clinical and Scientific Advisory Group (CSAG) met on 24th September 2015 and recommended 19 new tests for NHS service:

  • all of the new tests impact on care pathways within prescribed services with 2 also having an option to be requested for patients attending nephrology clinics funded by CCGs

  • 9 recommendations are panel tests that use Next Generation Sequencing (NGS) of which 3 are for Non Invasive Pre-natal Diagnosis

  • 1 recommendation uses Whole Genome Sequencing

  • 4 recommendations use Whole Exome Sequencing

  • of the 9 new tests using NGS, 3 of these have a number of sub panel tests that total 25

  • 8 were evaluated through the very rare disease process (less than 20 index cases a year and less than £5000 annual costs for index cases)

Please access the summary report for further details of these recommendations including a list of the tests, clinical benefits and financial implications.  Potential savings are a mix of actual savings (e.g. NGS tests replacing Sanger sequencing tests) and efficiencies as they release capacity for alternative use in the NHS (e.g. MRI no longer required for a patient that can have the genetic test instead). The testing services will be added to the online database of tests along with the Testing Criteria and Gene Dossiers.