Cardiomyopathies, Dilated (DCM), 22 Gene Panel

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Disorders	Symbol	MIM	Links
Atrial Fibrillation, Familial, 12	ATFB12	614050	Genetic Test Registry
Atrial Septal Defect 3	ASD3	614089	Genetic Test Registry
Cardiomyopathy, Dilated, 1A Cardiomyopathy, Congestive Cardiomyopathy, Dilated, With Conduction Defect 1 Cardiomyopathy, Familial Idiopathic Cardiomyopathy, Idiopathic Dilated	CMD1A CDCD1	115200	Genetic Test Registry
Cardiomyopathy, Dilated, 1AA, With Or Without Left Ventricular Noncompaction; Cardiomyopathy, Familial Hypertrophic, 23, With Or Without Ventricular Noncompaction, Included;	CMD1AA CMH23	612158	Genetic Test Registry
Cardiomyopathy, Dilated, 1CC	CMD1CC	613122	Genetic Test Registry
Cardiomyopathy, Dilated, 1D Left Ventricular Noncompaction 6, Included	CMD1D LVNC6, Included	601494	Genetic Test Registry
Cardiomyopathy, Dilated, 1DD	CMD1DD	613172	Genetic Test Registry
Cardiomyopathy, Dilated, 1EE	CMD1EE	613252	Genetic Test Registry
Cardiomyopathy, Dilated, 1FF	CMD1FF	613286	Genetic Test Registry
Cardiomyopathy, Dilated, 1G	CMD1G	604145	Genetic Test Registry
Cardiomyopathy, Dilated, 1I	CMD1I	604765	Genetic Test Registry
Cardiomyopathy, Dilated, 1J Cardiomyopathy, Dilated, With Sensorineural Hearing Loss, Autosomal Dominant	CMD1J	605362	Genetic Test Registry
Cardiomyopathy, Dilated, 1L	CMD1L	606685	Genetic Test Registry
Cardiomyopathy, Dilated, 1M	CMD1M	607482	Genetic Test Registry
Cardiomyopathy, Dilated, 1O Cardiomyopathy, Dilated, With Ventricular Tachycardia	CMD1O	608569	Genetic Test Registry
Cardiomyopathy, Dilated, 1P	CMD1P	609909	Genetic Test Registry
Cardiomyopathy, Dilated, 1R	CMD1R	613424	Genetic Test Registry
Cardiomyopathy, Dilated, 1S Left Ventricular Noncompaction 5	CMD1S LVNC5	613426	Genetic Test Registry
Cardiomyopathy, Dilated, 1T	CMD1T	613740	Genetic Test Registry
Cardiomyopathy, Dilated, 1W	CMD1W	611407	Genetic Test Registry
Cardiomyopathy, Dilated, 1Y Left Ventricular Noncompaction 9	CMD1Y LVNC9	611878	Genetic Test Registry
Cardiomyopathy, Dilated, 1Z	CMD1Z	611879	Genetic Test Registry
Cardiomyopathy, Dilated, 2A Cardiomyopathy, Congestive, Autosomal Recessive Cardiomyopathy, Dilated, Autosomal Recessive	CMD2A	611880	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 1 Asymmetric Septal Hypertrophy Cardiomyopathy, hypertrophic, 1, digenic Cardiomyopathy, Sporadic Hypertrophic, 1, Included Hypertrophic Subaortic Stenosis, Idiopathic Ventricular Hypertrophy, Hereditary	CMH1 ASH CMH	192600	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 11	CMH11	612098	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 12	CMH12	612124	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 13	CMH13	613243	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 14	CMH14	613251	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 15	CMH15	613255	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 18	CMH18	613874	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 2	CMH2	115195	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 20	CMH20	613876	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 25 Cardiomyopathy, Dilated, 1N	CMH25 CMD1N	607487	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 3	CMH3	115196	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 4	CMH4	115197	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 7	CMH7	613690	Genetic Test Registry
Cardiomyopathy, Familial Hypertrophic, 9	CMH9	613765	Genetic Test Registry
Cardiomyopathy, Familial Restrictive, 1	RCM1 RCM	115210	Genetic Test Registry
Cardiomyopathy, Familial Restrictive, 3	RCM3	612422	Genetic Test Registry
Left Ventricular Noncompaction 10 Cardiomyopathy, Dilated, 1MM	LVNC10 CMD1MM	615396	Genetic Test Registry

Genes	Symbol	MIM	HGNC
actin, alpha, cardiac muscle 1 actin, alpha actin, alpha, cardiac muscle smooth muscle actin	ACTC1 ACTC	102540	143
actinin, alpha 2	ACTN2	102573	164
ATP-binding cassette, sub-family C, member 9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 sulfonylurea receptor 2	ABCC9 SUR2	601439	60
cysteine and glycine rich protein 3 CLP LIM domain protein, muscle cysteine-rich protein 3 lim domain protein, cardiac	CSRP3 CRP3 MLP	600824	2472
desmin	DES	125660	2770
EYA transcriptional coactivator and phosphatase 4 eyes absent (Drosophila) homolog 4 eyes absent homolog 4 (Drosophila)	EYA4 CMD1J DFNA10	603550	3522
lamin A/C lamin A lamin C prelamin A	LMNA HGPS	150330	6636
myosin binding protein C, cardiac cardiac myosin-binding protein C myosin-binding protein C, cardiac	MYBPC3 CMH4 FHC MYBP-C MYBPC	600958	7551
myosin, heavy chain 6 myosin, heavy chain 6, cardiac muscle, alpha myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)	MYH6	160710	7576
myosin, heavy chain 7 myopathy, distal 1 myosin, cardiac, heavy chain, beta myosin, heavy chain 7, cardiac muscle, beta myosin, heavy polypeptide 7, cardiac muscle, beta	MYH7 CMD1S CMH1 MYHCB	160760	7577
nexilin F-actin binding protein nexilin (F actin binding protein)	NEXN	613121	29557
phospholamban	PLN PLB	172405	9080
RNA binding motif protein 20	RBM20	613171	27424
sarcoglycan delta sarcoglycan, delta (35kD dystrophin-associated glycoprotein) sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	SGCD	601411	10807
thymopoietin	TMPO	188380	11875
titin cardiomyopathy, dilated 1G (autosomal dominant connectin	TTN CMD1G	188840	12403
titin-cap limb girdle muscular dystrophy 2G (autosomal recessive) titin-cap (telethonin)	TCAP LGMD2G	604488	11610
tropomyosin 1 (alpha) cardiomyopathy, hypertrophic 3 chromosome 15 open reading frame 13 tropomyosin, skeletal muscle alpha	TPM1 C15orf13 CMH3 TMSA	191010	12010
troponin C1, slow skeletal and cardiac type "troponin C type 1 (slow)" TNNC, "troponin C type 1 (slow)" troponin C, slow	TNNC1 TNNC	191040	11943
troponin I3, cardiac type cardiomyopathy, dilated 2A (autosomal recessive) troponin I type 3 troponin I type 3 (cardiac) troponin I type 3 cardiac troponin I, cardiac	TNNI3 CMD2A CMH7 TNN13 TNNC1	191044	11947
troponin T2, cardiac type cardiomyopathy, dilated 1D (autosomal dominant) troponin T type 2 (cardiac) troponin t2, cardiac	TNNT2	191045	11949
vinculin	VCL	193065	12665

Gene dossier	Cardiac 67 Gene Panel Manchester RGC

Testing criteria	Cardiomyopathies, Dilated (DCM), 22 Gene Panel

Specialties	Cardiology, Adult Cardiology, Paediatric Clinical Genetics

1 laboratory offers this test:

Service level	Referral category	Laboratory	Calendar Days	NHS Price
Sequencing of the entire coding region of gene (s)	Postnatal Diagnosis Routine	Manchester RGC	112	£800
Testing for known mutations in family members	Postnatal Diagnosis Routine	Manchester RGC	28	£138
Testing for known mutations in family members	Postnatal Diagnosis Urgent	Manchester RGC	14	£138