New UKGTN Genetic Test Recommendations for NHS Service approved by the Clinical & Scientific Advisory Group March 2016

17 March 2016

The UKGTN Clinical and Scientific Advisory Group (CSAG) met on 15th March 2016 and recommended 14 new tests for NHS service:

  • all of the tests impact on care pathways within prescribed services with 1 test also having an option to be requested from nephrology clinics and 1 test being requested from immunology clinics funded by CCGs

  • 8 recommendations are panel tests that use Next Generation Sequencing (NGS) of which 1 is for Non Invasive Pre-natal Diagnosis

  • 2 recommendations use Whole Exome Sequencing (WES)

  • of the 8 new tests using NGS, 1 has 9 sub panel tests

  • 4 applications were evaluated through the very rare disease process (less than 20 index cases a year and less than £5000 annual costs for index cases)

Please access the summary report for further details of these recommendations including a list of the tests, clinical benefits and financial implications.  Potential savings are a mix of actual savings (e.g. NGS tests replacing Sanger sequencing tests) and efficiencies as they release capacity for alternative use in the NHS (e.g. MRI no longer required for a patient that can have the genetic test instead). The testing services will be added to the online database of tests along with the Testing Criteria and Gene Dossiers.